Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs.

@article{Fisher1997InsulinindependentAR,
  title={Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs.},
  author={Susan J. Fisher and Michael Lekas and Zhi Q. Shi and D L Bilinski and George Carvalho and Adria Giacca and Mladen Vranic},
  journal={Diabetes},
  year={1997},
  volume={46 11},
  pages={1805-12}
}
At rest and during exercise, chronic hyperglycemia, high free fatty acid (FFA) oxidation, and insulin deficiency in diabetes are well known to impair glucose clearance (metabolic clearance rate [MCR]). The effect of acute restoration of glycemia per se on MCR has been less well characterized. We therefore studied normal and alloxan-diabetic dogs both at rest and during exercise, as diabetic hyperglycemic or after acutely induced euglycemia (<160 min) generated by infusion of either insulin or… CONTINUE READING
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