Insulin increases the functional activity of the renal NaCl cotransporter

@article{ChvezCanales2013InsulinIT,
  title={Insulin increases the functional activity of the renal NaCl cotransporter},
  author={Mar{\'i}a Ch{\'a}vez-Canales and J. Arroyo and Benajmin Ko and N. V{\'a}zquez and R. Bautista and Mar{\'i}a Casta{\~n}eda-Bueno and N. Bobadilla and R. Hoover and G. Gamba},
  journal={Journal of Hypertension},
  year={2013},
  volume={31},
  pages={303–311}
}
Objectives: Insulin is recognized to increase renal salt reabsorption in the distal nephron and hyperinsulinemic states have been shown to be associated with increased expression of the renal NaCl cotransporter (NCC). However, the effect of insulin on NCC functional activity has not been reported. Methods: Using a heterologous expression system of Xenopus laevis oocytes, a mouse distal convoluted cell line, mDCT15 cells, endogenously expressing NCC, and an ex-vivo kidney perfusion technique, we… Expand
Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.
  • G. Gamba
  • Chemistry, Medicine
  • American journal of physiology. Renal physiology
  • 2012
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