Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle.

@article{Dyck2001InsulinIF,
  title={Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle.},
  author={David James Dyck and Gali Steinberg and Arend Bonen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 3},
  pages={E600-7}
}
We examined the effect of insulin on the synthesis and degradation of muscle lipid pools [phospholipid (PL), diacylglycerol (DG), triacylglycerol (TG)] and palmitate oxidation in isolated resting and contracting (20 tetani/min) soleus muscles. Lipid metabolism was monitored using the previously defined pulse-chase procedure. At rest, insulin significantly increased total palmitate uptake into soleus muscle (+49%, P < 0.05), corresponding to enhanced DG (+60%, P < 0.05) and TG (+61%, P < 0.05… CONTINUE READING

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Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle.

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Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptake.

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