Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake.

@article{Mebel2012InsulinIT,
  title={Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake.},
  author={Dmitry M Mebel and Jovi C.Y. Wong and Yifei Dong and Stephanie L Borgland},
  journal={The European journal of neuroscience},
  year={2012},
  volume={36 3},
  pages={
          2336-46
        }
}
Mesolimbic dopamine (DA) signaling has been implicated in the incentive, reinforcing and motivational aspects of food intake. Insulin receptors are expressed on dopaminergic neurons of the ventral tegmental area (VTA), and insulin may act in the VTA to suppress feeding. However, the neural mechanisms underlying insulin effects in the VTA are poorly understood. Here, we measured the effects of insulin on evoked DA concentration in the VTA using fast-scan cyclic voltammetry. Insulin concentration… CONTINUE READING
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