Insulin glargine metabolite 21A‐Gly‐human insulin (M1) is the principal component circulating in the plasma of young children with type 1 diabetes: results from the PRESCHOOL study

@article{Danne2015InsulinGM,
  title={Insulin glargine metabolite 21A‐Gly‐human insulin (M1) is the principal component circulating in the plasma of young children with type 1 diabetes: results from the PRESCHOOL study},
  author={Thomas Danne and Reinhard H. A. Becker and Lin Ping and Areti Philotheou},
  journal={Pediatric Diabetes},
  year={2015},
  volume={16}
}
Insulin glargine metabolite 21A‐Gly‐human insulin (M1) is the principal component circulating in plasma of adults with type 1 diabetes. The objective of this study was to confirm this finding in young children and to rule out accumulation of parent insulin glargine. 
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References

SHOWING 1-10 OF 21 REFERENCES
Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml
TLDR
Metabolites were quantified using immunoaffinity enrichment and liquid chromatography tandem mass spectrometry (LC‐MS/MS) and M1 was confirmed as the principal active moiety circulating in blood, the principal moiety responsible for metabolic effects, and subsequently into M2 in people with type 1 diabetes.
Plasma Exposure to Insulin Glargine and Its Metabolites M1 and M2 After Subcutaneous Injection of Therapeutic and Supratherapeutic Doses of Glargine in Subjects With Type 1 Diabetes
TLDR
After subcutaneous injection ofglargine in male subjects with type 1 diabetes, exposure to glargine is marginal, if any, even at supratherapeutic doses.
Lower HbA1c after 1 year, in children with type 1 diabetes treated with insulin glargine vs. NPH insulin from diagnosis: a retrospective study
TLDR
Lower HbA1c after 1 year, in children with type 1 diabetes treated with insulin glargine vs. NPH insulin from diagnosis: a retrospective study.
In Vitro Metabolic and Mitogenic Signaling of Insulin Glargine and Its Metabolites
TLDR
The binding of insulin glargine and its metabolites M1 and M2 to the IR were similar and correlated well with their corresponding autophosphorylation and metabolic activities in vitro, and this findings strongly support the idea that insulinglargine metabolites contribute with the same potency to blood glucose control but lead to significantly reduced growth-promoting activity.
Biotransformation of insulin glargine after subcutaneous injection in healthy subjects
TLDR
During treatment with a subcutaneous injection of insulin glargine, metabolic degradation is likely to be initiated at the injection site and continued within the circulatory system.
Flexible Insulin Therapy With Glargine Insulin Improved Glycemic Control and Reduced Severe Hypoglycemia Among Preschool-Aged Children With Type 1 Diabetes Mellitus
TLDR
The findings suggest that FMDI regimens may be a feasible therapeutic alternative to MDI treatment for preschool-aged children with type 1 DM, although excess body weight status appeared to preclude a desirable therapeutic response in this group of patients.
Does Insulin Glargine Increase the Risk of Cancer ComparedWith Other Basal Insulins? A French nationwide cohort study based on national administrative databases
TLDR
Cox proportional hazards models with age as timescale were used to calculate multivariate-adjusted hazard ratios for associations between type of basal insulin and risk of overall cancer, breast cancer, and seven other cancer sites.
Basal insulin and cardiovascular and other outcomes in dysglycemia.
TLDR
Although it reduced new-onset diabetes, insulin glargine also increased hypoglycemia and modestly increased weight and had a neutral effect on cardiovascular outcomes and cancers.
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