Insulin glargine: an updated review of its use in the management of diabetes mellitus.

@article{Dunn2003InsulinGA,
  title={Insulin glargine: an updated review of its use in the management of diabetes mellitus.},
  author={Christopher J. Dunn and Greg L. Plosker and Gillian M. Keating and Kate McKeage and Lesley J. Scott},
  journal={Drugs},
  year={2003},
  volume={63 16},
  pages={1743-78}
}
Insulin glargine is a human insulin analogue prepared by recombinant DNA technology. Modification of the human insulin molecule at position A21 and at the C-terminus of the B-chain results in the formation of a stable compound that is soluble at pH 4.0, but forms amorphous microprecipitates in subcutaneous tissue from which small amounts of insulin glargine are gradually released. The plasma concentration versus time profile of insulin glargine is therefore relatively constant in relation to… CONTINUE READING
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