Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

@article{Karlsson1990InsulinGE,
  title={Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain},
  author={Olof Karlsson and Stefan Thor and Torbj{\"o}rn Norberg and Helena Ohlsson and Thomas Edlund},
  journal={Nature},
  year={1990},
  volume={344},
  pages={879-882}
}
THE activity of the rat insulin I gene enhancer is mainly dependent on two cis-acting protein-binding domains1–3. Here we report the isolation of a complementary DNA encoding a protein, Isl-1, that binds to one of these domains. Isl-1 contains a homeodomain with greatest similarity to those of the Caenorhabditis elegans proteins encoded by mec-3 (ref. 4) and lin-11 (ref. 5). In addition, Isl-1, like the lin-11 and mec-3 gene products, contains a novel Cys–His domain which is reminiscent of… CONTINUE READING

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