Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase

@article{Madonna2004InsulinEV,
  title={Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase},
  author={Rosalinda Madonna and Assunta Pandolfi and Marika Massaro and Agostino Consoli and R. De Caterina},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={532-536}
}
Although hyperinsulinaemia in Type 2 diabetes in states of insulin resistance is a risk factor for atherosclerotic vascular disease, underlying mechanisms are poorly understood. We tested the hypothesis that insulin increases monocyte-endothelial interactions, which are implicated in atherosclerosis. We treated human umbilical vein endothelial cells with insulin (10−10 to 10−7 mol/l) for 0 to 24 h. To dissect potentially implicated signal transduction pathways, we treated endothelial cells with… CONTINUE READING
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