Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetes.

@article{Varu2010InsulinET,
  title={Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetes.},
  author={Vinit N. Varu and Sadie S Ahanchi and Melissa E. Hogg and Hussein A Bhikhapurwala and Amy Xin Chen and Daniel A. Popowich and Ashley K. Vavra and Janet Rodr{\'i}guez Mart{\'i}nez and Qun Guang Jiang and Joseph E. Saavedra and Joseph A. Hrabie and Larry Kay Keefer and Melina R Kibbe},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 3},
  pages={
          H772-9
        }
}
Diabetes confers greater restenosis from neointimal hyperplasia following vascular interventions. While localized administration of nitric oxide (NO) is known to inhibit neointimal hyperplasia, the effect of NO in type 1 diabetes is unknown. Thus the aim of this study was to determine the efficacy of NO following arterial injury, with and without exogenous insulin administration. Vascular smooth muscle cells (VSMC) from lean Zucker (LZ) rats were exposed to the NO donor, DETA/NO, following… CONTINUE READING

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