Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Abstract

Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal. However, the rising incidence of obesity, which results in chronically elevated insulin levels, implies that insulin may also act in brain centres that regulate motivation and reward. We report here that insulin can amplify action potential-dependent dopamine (DA… (More)
DOI: 10.1038/ncomms9543

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