Insulin enhances leptin expression in human trophoblastic cells.


Leptin, one of the adipokines that controls energy metabolism via the central nervous system, also has pleiotropic peripheral effects, acting as a proinflammatory cytokine. Leptin is also produced by trophoblastic cells in the placenta, where leptin seems to function as a trophic autocrine hormone. Leptin expression is regulated by various tissue-specific… (More)
DOI: 10.1095/biolreprod.113.109348


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