Insulin enhances l-dopa renal proximal tubule uptake: a regulatory mechanism impaired in insulin resistance

Abstract

A stimulatory role for insulin in the uptake of neutral amino acids has been reported for a variety of tissues. Here we examine the effect of insulin on l-dopa uptake by proximal tubule cells (PT cells) isolated from control and fructose-fed rats (FR-rats, 10% w/v fructose solution in tap water), a model of insulin resistance. Insulin (200 μU/ml) increased… (More)
DOI: 10.1007/s00424-003-1220-y

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