Insulin effects on myocardial function and bioenergetics in L-bupivacaine toxicity in the isolated rat heart.


BACKGROUND AND OBJECTIVES A positive effect of insulin-glucose-potassium infusion in severe bupivacaine-induced cardiovascular collapse has been described in vivo. It has been speculated that an antagonistic influence of insulin on sodium channel inhibition, transient outward potassium current, calcium-dependent adenosine triphosphatase or even improved… (More)


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