Insulin does not regulate glucose transport and metabolism in human endothelium.

@article{Artwohl2007InsulinDN,
  title={Insulin does not regulate glucose transport and metabolism in human endothelium.},
  author={Michaela Artwohl and Barbara Brunmair and Clemens F{\"u}rnsinn and Thomas Joachim H{\"o}lzenbein and Georg Rainer and Angelika Freudenthaler and E M Porod and Nicole Huttary and Sabina M. Baumgartner-Parzer},
  journal={European journal of clinical investigation},
  year={2007},
  volume={37 8},
  pages={643-50}
}
BACKGROUND Although endothelial cells express insulin receptors, it is controversially discussed whether the endothelium represents an insulin-responsive tissue. Since available data are primarily restricted to animal endothelial cells, this study tested (i) whether insulin affects glucose metabolism in human endothelium; (ii) whether insulin sensitivity is different in micro- versus macrovascular endothelial cells; and (iii) whether glucose concentration in the incubation medium affects the… CONTINUE READING