Insulin detemir causes increased symptom awareness during hypoglycaemia compared to human insulin.

@article{Tschritter2009InsulinDC,
  title={Insulin detemir causes increased symptom awareness during hypoglycaemia compared to human insulin.},
  author={Otto Tschritter and Silke Sch{\"a}fer and Jens Klett and Albrecht Pfaefflin and H G H{\"a}ring and Anita M. Hennige and Andreas Fritsche},
  journal={Diabetes, obesity & metabolism},
  year={2009},
  volume={11 11},
  pages={1017-26}
}
AIM The long-acting insulin analogue detemir (Levemir) has structural and physicochemical properties which differ from human insulin. The aim of the present study was to test whether this leads to altered hormone and symptom response during hypoglycaemia. METHODS 12 healthy subjects [6f/6m, age 32 +/- 6 years (mean +/- s.d.), body mass index (BMI) 24.2 +/- 2.5 kg/m(2)] underwent a 200-min stepwise hypoglycaemic clamp (45 min steps of 4.4, 3.7, 3.0 and 2.3 mmol/l) with either detemir or human… CONTINUE READING

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