Insulin-dependent signaling regulates azurophil granule-selective macroautophagy in human myeloblastic cells.

@article{Saeki2003InsulindependentSR,
  title={Insulin-dependent signaling regulates azurophil granule-selective macroautophagy in human myeloblastic cells.},
  author={Kumiko Saeki and Zhang Hong and Masami Nakatsu and Tamotsu Yoshimori and Yukiko Kabeya and Akitsugu Yamamoto and Yasushi Kaburagi and Akira Yuo},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={74 6},
  pages={1108-16}
}
We show that insulin-dependent signals regulate azurophil granule-selective macroautophagy in human myeloid cells. Depletion of insulin from an insulin-transferrin-supplemented serum-free medium caused growth retardation of myeloblastic HL-60 cells, in which sequestration of electronic-dense cytoplasmic materials by autophagosomes was observed. Positive immunoreactivity with anti-CD68, anti-cathepsin D, and anti-myeloperoxidase antibodies indicated that the sequestrated materials were azurophil… CONTINUE READING

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