Insulin-dependent leptin expression in breast cancer cells.

Abstract

Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression in an autocrine or paracrine way. Using… (More)
DOI: 10.1158/0008-5472.CAN-08-0642

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