Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).

@article{Foster2006InsulindependentIO,
  title={Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).},
  author={Leonard J. Foster and Assaf Rudich and Ilana Talior and Nish Patel and Xudong Huang and L Michelle Furtado and Philip J. Bilan and Matthias Mann and Amira Klip},
  journal={Journal of proteome research},
  year={2006},
  volume={5 1},
  pages={64-75}
}
The insulin-regulated glucose transporter (GLUT4) translocates to the plasma membrane in response to insulin in order to facilitate the postprandial uptake of glucose into fat and muscle cells. While early insulin receptor signaling steps leading to this translocation are well defined, the integration of signaling and regulation of GLUT4 traffic remains elusive. Several lines of evidence suggest an important role for the actin cytoskeleton and for protein-protein interactions in regulating… CONTINUE READING
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