Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.

  title={Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.},
  author={Michele P. Marron and Leslie J. Raffel and Henri-Jean Garchon and Chaim O. Jacob and Manuel Serrano-R{\'i}os and Maria Teresa Mart{\'i}nez Larrad and W P Teng and Yongsoo Park and Z X Zhang and Darlene R. Goldstein and Yong Tao and Genevi{\`e}ve Beaurain and J. F. Bach and H-J. Su Huang and Deru Luo and Adina Zeidler and Jerome I. Rotter and Michael C. Yang and Tamara Modilevsky and Noel K. Maclaren and Jin Xiong She},
  journal={Human molecular genetics},
  volume={6 8},
Linkage disequilibrium (association) analysis was used to evaluate a candidate region near the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children affected by IDDM. In the data set unique to this study (Spanish, French, Mexican-American, Chinese and Korean), the transmission/disequilibrium test (TDT) revealed a highly significant deviation for transmission of alleles at the (AT)n microsatellite marker in the 3' untranslated region (P = 0.002) and the A/G… CONTINUE READING
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Independent association of HLA-DPB1*0301 with insulin-dependent diabetes mellitus

  • H. A. Erlich, J. I. Rotter, +5 authors A. Zeidler
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