Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart

@article{Nerurkar1988InsulindependentCI,
  title={Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart},
  author={M. A. Nerurkar and Jagannath G. Satav and Surendra S. Katyare},
  journal={Diabetologia},
  year={1988},
  volume={31},
  pages={119-122}
}
Streptozotocin-induced diabetes rsulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values. 

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