Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.

@article{Federici2002InsulindependentAO,
  title={Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.},
  author={Massimo Federici and Rossella Menghini and Alessandro Mauriello and Marta Letizia Hribal and Francesca Ferrelli and Davide Lauro and Paolo Sbraccia and Luigi Giusto Spagnoli and Giorgio Sesti and Renato Lauro},
  journal={Circulation},
  year={2002},
  volume={106 4},
  pages={
          466-72
        }
}
BACKGROUND Hyperglycemia impairs functional properties of cytosolic and nuclear proteins via O-linked glycosylation modification (O-GlcNAcylation). We studied the effects of O-GlcNAcylation on insulin signaling in human coronary artery endothelial cells. METHODS AND RESULTS O-GlcNAcylation impaired the metabolic branch of insulin signaling, ie, insulin receptor (IR) activation of the IR substrate (IRS)/phosphatidylinositol 3-kinase (PI3-K)/Akt, whereas it enhanced the mitogenic branch, ie… CONTINUE READING
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2001