Insulin-degrading enzyme regulates the levels of insulin , amyloid-protein , and the-amyloid precursor protein intracellular domain in vivo

@inproceedings{Farris2003InsulindegradingER,
  title={Insulin-degrading enzyme regulates the levels of insulin , amyloid-protein , and the-amyloid precursor protein intracellular domain in vivo},
  author={Wesley Farris and Stefan Mansourian and Yang Sil Chang and Loren Lindsley and Elizabeth A. Eckman and Matthew P. Frosch and Christopher B. Eckman and Rudolph E. Tanzi and Dennis J Selkoe and Suzanne Y. Gu{\'e}nette},
  year={2003}
}
Two substrates of insulin-degrading enzyme (IDE), amyloid -protein (A ) and insulin, are critically important in the pathogenesis of Alzheimer’s disease (AD) and type 2 diabetes mellitus (DM2), respectively. We previously identified IDE as a principal regulator of A levels in neuronal and microglial cells. A small chromosomal region containing a mutant IDE allele has been associated with hyperinsulinemia and glucose intolerance in a rat model of DM2. Human genetic studies have implicated the… CONTINUE READING
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