Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.

  title={Insulin-degrading enzyme is activated by the C-terminus of α-synuclein.},
  author={Sandeep K Sharma and Erik Chorell and Pernilla Wittung-Stafshede},
  journal={Biochemical and biophysical research communications},
  volume={466 2},
The insulin-degrading enzyme (IDE) plays a key role in type-2 diabetes and typically degrades small peptides such as insulin, amyloid β and islet amyloid polypeptide. We recently reported a novel non-proteolytical interaction in vitro between IDE and the Parkinson's disease 140-residue protein α-synuclein that resulted in dual effects: arrested α-synuclein oligomers and, simultaneously, increased IDE proteolysis activity. Here we demonstrate that these outcomes arise due to IDE interactions… CONTINUE READING