Insulin-degrading enzyme: embarking on amyloid destruction.

@article{Kurochkin2001InsulindegradingEE,
  title={Insulin-degrading enzyme: embarking on amyloid destruction.},
  author={I. V. Kurochkin},
  journal={Trends in biochemical sciences},
  year={2001},
  volume={26 7},
  pages={421-5}
}
Several human disorders are caused by or associated with the deposition of protein aggregates known as amyloid fibrils. Despite the lack of sequence homology among amyloidogenic proteins, all amyloid fibrils share a common morphology, are insoluble under physiological conditions and are resistant to proteolytic degradation. Because amyloidogenic proteins are being produced continuously, eukaryotic organisms must have developed a form of proteolytic machinery capable of controlling these… CONTINUE READING

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