Insulin degradation: mechanisms, products, and significance.

  title={Insulin degradation: mechanisms, products, and significance.},
  author={William C. Duckworth},
  journal={Endocrine reviews},
  volume={9 3},
Although much remains to be learned, our understanding of the mechanisms and processes by which insulin is degraded has advanced considerably over the past few years. The roles of receptor binding and internalization in mediating insulin degradation have been clarified, and the endosomal pathway for intracellular insulin degradation has been established and partially characterized. The importance of IP (IDE) in cellular insulin degradation has been established and the importance of lysosomal… CONTINUE READING

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