Insulin cooperates with IL-1 in regulating expression of alpha 1-acid glycoprotein gene in rat hepatoma cells.

@article{Campos1994InsulinCW,
  title={Insulin cooperates with IL-1 in regulating expression of alpha 1-acid glycoprotein gene in rat hepatoma cells.},
  author={Susana P Campos and Yijie Wang and Aleksander Koj and Heinz Baumann},
  journal={Cytokine},
  year={1994},
  volume={6 5},
  pages={485-92}
}
Insulin treatment of the rat hepatoma H-35 cells results in a reduced stimulation of acute phase plasma protein gene expression by IL-1- and IL-6-type cytokines. The cell response to insulin appears to involve both stimulatory and inhibitory regulatory mechanisms because a clonal variant line of the H-35 cells has been identified in which insulin increases specifically the IL-1 stimulation of alpha 1-acid glycoprotein (AGP) gene, while still reducing the expression of the other acute phase… CONTINUE READING