Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.

@article{Huang2001InsulinCR,
  title={Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein.},
  author={Jianyong Huang and Takeshi Imamura and Jerrold M. Olefsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 23},
  pages={13084-9}
}
Insulin stimulates glucose transport by promoting translocation of the insulin-sensitive glucose transporter isoform 4 (GLUT4) from an intracellular compartment to the cell surface. This movement is accomplished by stimulation of GLUT4 exocytosis as well as inhibition of endocytosis. However, the molecular mechanisms for these effects remain unclear. In this study, we found that the GTP-binding protein Rab5 physically associated with the motor protein dynein in immunoprecipitants from both… CONTINUE READING

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