Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans.

@article{Lembo1994InsulinBS,
  title={Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans.},
  author={Giuseppe Lembo and Guido Iaccarino and Virgilio Rendina and Massimo Volpe and Bruno Trimarco},
  journal={Hypertension},
  year={1994},
  volume={24 4},
  pages={429-38}
}
We investigated the mechanisms underlying the insulin-induced attenuation of sympathetic forearm vasoconstriction in healthy humans. In 5 subjects, we applied 20 mm Hg lower body negative pressure for 30 minutes in control conditions and during a 60-minute infusion of insulin (0.05 mU/kg per minute) in the brachial artery and measured forearm norepinephrine kinetics and hemodynamics. In 11 subjects, we applied graded lower body negative pressure at 5, 10, 15, and 20 mm Hg for 5 minutes each in… CONTINUE READING

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