Insulin blocks cytochrome c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding.

@article{Sanderson2008InsulinBC,
  title={Insulin blocks cytochrome c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding.},
  author={Thomas H Sanderson and Rita Kumar and Jonathon M Sullivan and Gary S. Krause},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 3},
  pages={1248-58}
}
The critical event of the intrinsic pathway of apoptosis following transient global brain ischemia is the release of cytochrome c from the mitochondria. In vitro studies have shown that insulin can signal specifically via phosphatidylinositol-3-OH-kinase (PI3-K) and Akt to prevent cytochrome c release. Therefore, insulin may exert its neuroprotective effects during brain reperfusion by blocking cytochrome c release. We hypothesized that insulin acts through PI3-K, Akt, and Bcl-2 family proteins… CONTINUE READING

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