Insulin biosynthesis in the rat: demonstration of two proinsulins.


Proinsulin, a single-chain precursor of insulin, has been detected in biosynthetic studies in vitro,(1-4) and in crystalline preparations of insulin from several species.(1, 5-7) It appears that proinsulin normally serves neither as a major storage nor secretory form of the hormone.(8) Its primary functions seems to be to facilitate the efficient formation… (More)


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