Insulin attenuates vasopressin-induced calcium transients and a voltage-dependent calcium response in rat vascular smooth muscle cells.

@article{Standley1991InsulinAV,
  title={Insulin attenuates vasopressin-induced calcium transients and a voltage-dependent calcium response in rat vascular smooth muscle cells.},
  author={Paul R Standley and Fan Zhang and Jeffrey L. Ram and Michael B Zemel and James R. Sowers},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={88 4},
  pages={1230-6}
}
Insulin attenuates the contractile responses of vascular smooth muscle (VSM) to various agonists. Insulinopenic and insulin-resistant rats lack this normal attenuation of vascular contractile responses. To study this attenuating mechanism, the effects of insulin on calcium (Ca2+) responses of cultured VSM cells (a7r5) to arginine vasopressin (AVP) and membrane potential were investigated. Insulin (1 and 100 mU/ml) shifted AVP dose-response curves to the right, reducing relative potency of AVP… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

Insulin resistance and hypertension

  • S. Hulman, J. Tannenbaum
  • Mol . Cell . Endo - crinol .
  • 1990

Vascular reactivity in Zucker obese rats : role of insulin resistance

  • S. Reddy, S. E. Shehin, W. Lockette
  • J . Vasc . Med . Biol .
  • 1990

Insulin resistance in essential hypertension

  • R. Bonadonna, M. A. Giorico, +4 authors S. Bevilacqua
  • N . Engl . J . Med .
  • 1987

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