Insulin attenuates the stimulatory effects of tumor necrosis factor alpha on 11beta-hydroxysteroid dehydrogenase 1 in human adipose stromal cells.

@article{Handoko2000InsulinAT,
  title={Insulin attenuates the stimulatory effects of tumor necrosis factor alpha on 11beta-hydroxysteroid dehydrogenase 1 in human adipose stromal cells.},
  author={Kim B Handoko and Kaiping Yang and Brenda J Strutt and Wajahat Khalil and D. Killinger},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2000},
  volume={72 3-4},
  pages={163-8}
}
Obesity is frequently associated with insulin-resistance and abnormal glucose homeostasis. Recent evidence indicates that TNFalpha may play a role in mediating the insulin-resistance of obesity through its overexpression in adipose tissue. Previously, we have shown that human adipose stromal cells contain 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mRNA and activity. The present study was designed to examine the effects of insulin on 11beta-HSD1 expression in human adipose stromal… CONTINUE READING