Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression.

@article{Klein2000InsulinAT,
  title={Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression.},
  author={Jerome O. Klein and Mathias Fasshauer and Manuel Benito and C Ronald Kahn},
  journal={Molecular endocrinology},
  year={2000},
  volume={14 6},
  pages={764-73}
}
Cross-talk between insulin and the adrenergic system is important in the regulation of energy homeostasis. In cultured, differentiated mouse brown adipocytes, beta3-adrenergic stimulation induced a 4.5-fold increase in uncoupling protein-1 (UCP-1) expression, which was diminished by 25% in the presence of insulin. Beta3-adrenergic stimulation also activated mitogen-activated protein (MAP) kinase by 3.5-fold and caused a decrease in basal phosphoinositide (PI) 3-kinase activity detected in… CONTINUE READING

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