Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target.

@article{Lay2002InsulinAS,
  title={Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target.},
  author={Soazig Le Lay and Isabelle Lefr{\`e}re and Francisco Javier Cubero and Isabelle Dugail and St{\'e}phane Krief},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 38},
  pages={35625-34}
}
We evaluated the hypothesis of sterol-regulatory element-binding protein (SREBP)-1c being a general mediator of the transcriptional effects of insulin, with a focus on adipocytes, in which insulin profoundly influences specific gene expression. Using real time quantitative reverse transcriptase-PCR to monitor changes in the expression of about 50 genes that cover a wide range of adipocyte functions, we have compared the impact of insulin treatment with that of adenoviral overexpression of… CONTINUE READING
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