Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade.

@article{Rodrguez2011InsulinAL,
  title={Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade.},
  author={Amaia Rodr{\'i}guez and Victoria Catal{\'a}n and Javier G{\'o}mez-Ambrosi and Socorro Garc{\'i}a-Navarro and Fernando Rotellar and Victor Valenti and Caroline Silva and M. J. Gil and Javier Salvador and Mar{\'i}a Angela Burrell and Giuseppe Calamita and Mar{\'i}a Del Mar Malag{\'o}n and Gema Fr{\"u}hbeck},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 4},
  pages={E586-97}
}
OBJECTIVE Glycerol constitutes an important metabolite for the control of lipid accumulation and glucose homeostasis. The impact of obesity and obesity-associated type 2 diabetes as well as the potential regulatory role of insulin and leptin on aquaglyceroporins (AQP) 3, 7, and 9 were analyzed. RESEARCH DESIGN AND METHODS The tissue distribution and expression of AQP in biopsies of omental and sc adipose tissue as well as liver were analyzed in lean and obese Caucasian volunteers (n = 63… CONTINUE READING
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