Insulin and leptin as adiposity signals.

  title={Insulin and leptin as adiposity signals.},
  author={Stephen C. Benoit and Deborah J. Clegg and Randy J Seeley and Stephen Woods},
  journal={Recent progress in hormone research},
There is now considerable consensus that the adipocyte hormone leptin and the pancreatic hormone insulin are important regulators of food intake and energy balance. Leptin and insulin fulfill many of the requirements to be putative adiposity signals to the brain. Plasma leptin and insulin levels are positively correlated with body weight and with adipose mass in particular. Furthermore, both leptin and insulin enter the brain from the plasma. The brain expresses both insulin and leptin… CONTINUE READING
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