Insulin and insulin-like growth factor I signaling pathways in rainbow trout (Oncorhynchus mykiss) during adipogenesis and their implication in glucose uptake.

@article{Bouraoui2010InsulinAI,
  title={Insulin and insulin-like growth factor I signaling pathways in rainbow trout (Oncorhynchus mykiss) during adipogenesis and their implication in glucose uptake.},
  author={Lamia Bouraoui and Encarnaci{\'o}n Capilla and Joaquim Guti{\'e}rrez and Isabel Navarro},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={299 1},
  pages={
          R33-41
        }
}
  • L. Bouraoui, E. Capilla, +1 author I. Navarro
  • Published 1 July 2010
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Primary cultures of rainbow trout (Oncorhynchus mykiss) adipocytes were used to examine the main signaling pathways of insulin and insulin-like growth factor I (IGF-I) during adipogenesis. We first determined the presence of IGF-I receptors (IGF-IR) and insulin receptors (IR) in trout preadipocytes (day 5) and adipocytes (day 14). IGF-IRs were more abundant and appeared to be in higher levels in differentiated cells than in preadipocytes, whereas IRs were detected in lower but constant levels… 
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References

SHOWING 1-10 OF 64 REFERENCES
Metabolic and mitogenic effects of IGF-II in rainbow trout (Oncorhynchus mykiss) myocytes in culture and the role of IGF-II in the PI3K/Akt and MAPK signalling pathways.
IGF-I and insulin receptor signal transduction in trout muscle cells.
TLDR
The present study demonstrates that purified trout insulin receptors possess higher phosphorylative activity per unit of receptor than IGF-I receptors and that there is a different regulation of MAPK and Akt pathways depending on the developmental stage of the muscle cells.
Metabolic and mitogenic effects of IGF-I and insulin on muscle cells of rainbow trout.
TLDR
It is concluded that IGF-I is more effective than insulin in stimulating glucose and alanine uptake in rainbow trout myosatellite cells and that the degree of stimulation changes when cells differentiate to myotubes.
The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes.
TLDR
It is hypothesized that down-regulation of MAPK via loss of proximal signaling through Shc is an early component in the IGF-I switch from mitogenesis to differentiation in 3T3-L1 preadipocyte differentiation.
Insulin and IGF-I receptors in trout adipose tissue are physiologically regulated by circulating hormone levels.
TLDR
The results demonstrate for the first time the presence of specific insulin and IGF-I receptors in adipose tissue of ectothermic vertebrates and suggest that adipOSE tissue may be a target for the actions of insulin and insulin-like growth factor I in fish.
Expression and function of insulin/insulin-like growth factor I hybrid receptors during differentiation of 3T3-L1 preadipocytes.
TLDR
It is conclusion that hybrid insulin/IGF receptors can transduce a transmembrane signal when activated by IGF-I, and biological actions in 3T3-L1 adipocytes, previously attributed to archetypal IGF receptors, are in fact mediated through hybrid receptors.
Regulation of proliferation and differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchus mykiss).
TLDR
The culture system described here for trout pre-adipocytes is a powerful tool to study the endocrine regulation of adipogenesis in this species and indicates that transcriptional factors are involved in adipocyte differentiation in trout.
Differential Roles of the Insulin and Insulin-like Growth Factor-I (IGF-I) Receptors in Response to Insulin and IGF-I*[boxs]
TLDR
Results indicate that the insulin and IGF-I receptors contribute distinct signals to common downstream components in response to both insulin and insulin-like growth factor-I.
Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes.
TLDR
An essential requirement of PI 3-kinase in the IGF-I-signaling pathways leading to fetal brown adipocyte differentiation, but not leading to mitogenesis is shown for the first time.
Modulation of insulin-like growth factor I mitogenic signaling in 3T3-L1 preadipocyte differentiation.
TLDR
The change in IGF-I signaling via Shc phosphorylation and MAPK activity during 3T3-L1 differentiation indicates that loss of IGF- I mitogenic signaling via the MAPK pathway is part of the differentiation process.
...
1
2
3
4
5
...