Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors.

@article{Verspohl1988InsulinAI,
  title={Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors.},
  author={Eugen J. Verspohl and Betty A. Maddux and Ira D Goldfine},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1988},
  volume={67 1},
  pages={169-74}
}
The receptors for insulin and insulin-like growth factor I (IGF-I) are closely related molecules, with an extracellular binding domain and an intracellular tyrosine kinase domain. The interaction of insulin and IGF-I with their respective receptors activates the receptor kinase domain, leading to the biological actions of the hormones. Since insulin generally regulates metabolic events and IGF-I generally regulates growth events, it is believed that structural differences in the tyrosine kinase… CONTINUE READING

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