Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells.

@article{Li2009InsulinAI,
  title={Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells.},
  author={Guolian Li and Eugene J. Barrett and Seung-Hyun B. Ko and Wenhong Cao and Zhen-qi Liu},
  journal={Endocrinology},
  year={2009},
  volume={150 8},
  pages={3475-82}
}
Patients with type 2 diabetes are hyperinsulinemic and insulin resistant and develop premature atherosclerosis. High concentrations of insulin stimulate the production of adhesion molecules by endothelial cells (ECs). ECs express abundant IGF-I receptors as well as insulin receptors. Whether IGF-I receptors contribute to insulin-induced endothelial production of adhesion molecules is unknown. Bovine aortic ECs (BAECs) were incubated with insulin (100 nm) for 24 h. The cellular content of… CONTINUE READING

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