Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.

@article{Dupont2001InsulinAI,
  title={Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.},
  author={Jo{\"e}lle Dupont and Derek Leroith},
  journal={Hormone research},
  year={2001},
  volume={55 Suppl 2},
  pages={22-6}
}
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha-subunits and two transmembrane beta-subunits. They share a high similarity of structure and intracellular signalling events. However, the IR and the IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis and differentiation. Although some of the variation can be attributed to a different tissue distribution… CONTINUE READING

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