Insulin and glucagon release of human islets in vitro: effects of chronic exposure to glucagon.

  title={Insulin and glucagon release of human islets in vitro: effects of chronic exposure to glucagon.},
  author={Federico Bertuzzi and Cesare Berra and Carlo Socci and Alberto M. Davalli and Guido Pozza and Antonio E. Pontiroli},
  journal={The Journal of endocrinology},
  volume={152 2},
Hyperglucagonemia is commonly found in insulin-dependent as well as in non-insulin-dependent diabetes mellitus, and is likely to be caused by absolute or relative insulin deficiency. The aim of the present study was to evaluate whether a chronic glucagon exposure (1.0 microM for 4 h) modifies the insulin response to acute stimuli with glucagon (1.0 microM), arginine (10.0 mM) and glucose (16.7 mM), or the glucagon response to arginine and glucose, in human islets. Chronic exposure to glucagon… Expand
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