Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

@inproceedings{Cardoso2009InsulinAI,
  title={Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets},
  author={Susana M Cardoso and Renato X. Santos and S{\'o}nia Catarina Correia and Cristina Isabel Carvalho and Xiongwei Zhu and Hyoung-Gon Lee and Gemma Casades{\'u}s and Mark A. Smith and George Perry and Paula I Moreira},
  booktitle={Pharmaceuticals},
  year={2009}
}
Insulin, besides its glucose lowering effects, is involved in the modulation of lifespan, aging and memory and learning processes. As the population ages, neurodegenerative disorders become epidemic and a connection between insulin signaling dysregulation, cognitive decline and dementia has been established. Mitochondria are intracellular organelles that despite playing a critical role in cellular metabolism are also one of the major sources of reactive oxygen species. Mitochondrial dysfunction… CONTINUE READING

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