Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

@inproceedings{Garwood2015InsulinAI,
  title={Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors},
  author={Claire J Garwood and Laura E. Ratcliffe and Sarah V. Morgan and Julie E. Simpson and Helen Owens and Irina Vazquez-Villase{\~n}or and Paul R Heath and Ignacio Andres Romero and Paul G. Ince and Stephen Barrie Wharton},
  booktitle={Molecular Brain},
  year={2015}
}
The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation and are dysregulated in neurons in Alzheimer’s disease (AD). We previously showed downregulation in IIS gene expression in astrocytes with AD-neuropathology progression, but IIS in astrocytes remains poorly understood. We therefore examined the IIS pathway in human astrocytes and developed models to reduce IIS at the level of the insulin or the IGF1 receptor (IGF1R). We determined IIS was present and functional in… CONTINUE READING

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