Insulin and IGF-I receptors signaling in protection from apoptosis.

  title={Insulin and IGF-I receptors signaling in protection from apoptosis.},
  author={Marco Prisco and Gaetano Romano and Francesca Peruzzi and Barbara Valentinis and Renato Baserga},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={31 2-3},
R-cells are mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor (IGF-IR) genes. Because R-cells do not express the IGF-IR, they are ideal for studying the biological effects of the insulin receptor (IR), independently from any contribution by the IGF-IR. By stably transfecting R-cells with constructs expressing the IR, we show here the IR can protect cells from apoptosis induced by anoikis or by okadaic acid. The IR, however, is not as efficient as… CONTINUE READING

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