Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

@article{DesboisMouthon2001InsulinAI,
  title={Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation},
  author={Christ{\`e}le Desbois-Mouthon and Axelle Cadoret and Marie-Jos{\'e} Blivet-Van Eggelpo{\"e}l and France Bertrand and Gis{\`e}le Cherqui and Christine Perret and Jacqueline Capeau},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={252-259}
}
  • Christèle Desbois-Mouthon, Axelle Cadoret, +4 authors Jacqueline Capeau
  • Published in Oncogene 2001
  • DOI:10.1038/sj.onc.1204064
We examined the interplay between the insulin/IGF-1- and β-catenin-regulated pathways, both of which are suspected to play a role in hepatocarcinogenesis. Insulin and IGF-1 stimulated the transcription of a Lef/Tcf-dependent luciferase reporter gene by 3–4-fold in HepG2 cells. This stimulation was mediated through the activation of phosphatidylinositol 3-kinase (PI 3-K)/Akt and the inhibition of glycogen synthase kinase-3β (GSK-3β) since the effects of insulin and IGF-1 were inhibited by… CONTINUE READING

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The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis.

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References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Am

JT Nhieu, CA Renard, +3 authors MA. Buendia
  • J. Pathol., 155, 703 ± 710.
  • 1999
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Curr

P. Polakis
  • Opin. Genet. Dev., 9, 15 ± 21.
  • 1999
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

J

CC Weihl, GD Ghadge, +3 authors RP. Roos
  • Neurosci., 19, 5360 ± 5369.
  • 1999
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Proc

A De La Coste, B Romagnolo, +8 authors C. Perret
  • Natl. Acad. Sci. USA, 95, 8847 ± 8851.
  • 1998
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Biochem

DAE Cross, DR Alessi, +3 authors P. Cohen
  • J., 303, 21 ± 26.
  • 1994
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Adv

N Barker, PJ Morin, H. Clevers
  • Cancer Res., 77, 1 ± 24.
  • 2000
VIEW 2 EXCERPTS

J

H Yuan, J Mao, L Li, W. Dianqing
  • Biol. Chem., 43, 30419 ± 30423. Oncogene
  • 1999

J

J Espada, M Pe rez-Moreno, VMM Braga, P RodriguezViciana, A. Cano
  • Cell Biol., 146, 967 ± 980.
  • 1999

J

SA Summers, AW Kao, +4 authors MJ. Birnbaum
  • Biol. Chem., 274, 17934 ± 17940.
  • 1999

Mol

MA Torres, H Eldar-Finkelman, EG Krebs, RT. Moon
  • Cell. Biol., 19, 1427 ± 1437.
  • 1999

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