Insulin and Atheroma: 20-Yr Perspective

  title={Insulin and Atheroma: 20-Yr Perspective},
  author={Robert W. Stout},
  journal={Diabetes Care},
  pages={631 - 654}
  • R. Stout
  • Published 1 June 1990
  • Medicine, Biology
  • Diabetes Care
Many clinical studies have shown an increased insulin response to oral glucose in patients with ischemia of the heart, lower limbs, or brain. Hyperinsulinemia also occurs in patients with angiographically proved atherosclerosis without ischemia and thus appears to be related to arterial disease and not to be a nonspecific response to tissue injury. Fasting insulin levels and insulin responses to intravenous stimuli, including glucose, tolbutamide, and arginine, are normal, suggesting a… 

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