Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.

  title={Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.},
  author={Q. K. Fu and Qingtong Wang and Yang K Xiang},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={28 6},
Recent advances show that insulin may affect β adrenergic receptor (βAR) signaling in the heart to modulate cardiac function in clinically relevant states, such as diabetes mellitus (DM) and heart failure (HF). Conversely, activation of βAR regulates cardiac glucose uptake and promotes insulin resistance (IR) in HF. Here, we discuss the recent characterization of the interaction between the cardiac insulin receptor (InsR) and βAR in the myocardium, in which insulin stimulation crosstalks with… CONTINUE READING


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