Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity.

Abstract

In this study, we prepared several shortened and full-length insulin analogues with substitutions at position B26. We compared the binding affinities of the analogues for rat adipose membranes with their ability to lower the plasma glucose level in nondiabetic Wistar rats in vivo after subcutaneous administration, and also with their ability to stimulate… (More)
DOI: 10.1021/bi702086w

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