Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes

@article{Hermansen2004InsulinA,
  title={Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with Type 1 diabetes},
  author={K. Hermansen and P. Fontaine and K. K. Kukolja and V. Peterkova and G. Leth and M.-A. Gall},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={622-629}
}
Aims/hypothesisThe aim of the trial was to compare the efficacy and tolerability of two types of basal-bolus therapy, using either the soluble long-acting basal insulin analogue, insulin detemir, in combination with the rapid-acting analogue, insulin aspart, or NPH insulin in combination with mealtime regular human insulin.MethodsIn this 18-week, 1:1 randomised, open-labelled, parallel trial, 595 patients with Type 1 diabetes mellitus received insulin detemir or NPH insulin in the morning and… Expand
349 Citations

Paper Mentions

Interventional Clinical Trial
This trial is conducted in Europe and South America. The aim of this trial is to compare the glycaemic control of insulin detemir plus insulin aspart with that of insulin NPH plus human… Expand
ConditionsDiabetes, Diabetes Mellitus, Type 1
InterventionDrug
Rapid-acting insulin analogues in Basal-bolus regimens in type 1 diabetes mellitus.
  • S. Garg, F. J. Ampudia-Blasco, M. Pfohl
  • Medicine
  • Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2010
  • 20
Insulin Detemir in the Treatment of Type 1 and Type 2 Diabetes
  • 15
  • PDF
Insulin Aspart
  • 11
Treatment of Type 1 and Type 2 Diabetes Mellitus with Insulin Detemir, a Long-Acting Insulin Analog
  • 7
  • PDF
Pre-meal insulin aspart compared with pre-meal soluble human insulin in type 1 diabetes.
  • 34
A review of human and analogue insulin trials.
  • S. Gough
  • Medicine
  • Diabetes research and clinical practice
  • 2007
  • 119
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
New insulins in the treatment of diabetes mellitus.
  • A. Lindholm
  • Medicine
  • Best practice & research. Clinical gastroenterology
  • 2002
  • 75
Use of insulin aspart, a fast-acting insulin analog, as the mealtime insulin in the management of patients with type 1 diabetes.
  • 235
  • Highly Influential
  • PDF
Improved postprandial glycemic control with insulin aspart. A randomized double-blind cross-over trial in type 1 diabetes.
  • 171
Reducing hypoglycaemia with insulin analogues
  • S. Heller
  • Medicine
  • International Journal of Obesity
  • 2002
  • 32
  • PDF
Insulin analogues: have they changed insulin treatment and improved glycaemic control?
  • S. Madsbad
  • Medicine
  • Diabetes/metabolism research and reviews
  • 2002
  • 19
...
1
2
3
...