Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts.

@article{Santos2004InsulinAV,
  title={Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts.},
  author={Anne Navarrete Santos and Sarah Tonack and Michaela Kirstein and Marie Pantaleon and Peter L Kaye and Bernd Fischer},
  journal={Reproduction},
  year={2004},
  volume={128 5},
  pages={517-26}
}
The addition of insulin during in vitro culture has beneficial effects on rabbit preimplantation embryos leading to increased cell proliferation and reduced apoptosis. We have previously described the expression of the insulin receptor (IR) and the insulin-responsive glucose transporters (GLUT) 4 and 8 in rabbit preimplantation embryos. However, the effects of insulin on IR signaling and glucose metabolism have not been investigated in rabbit embryos. In the present study, the effects of 170 nM… CONTINUE READING

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Recent advances in our understanding of insulin action and insulin resistance

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Highly Influential
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